• Western blot analysis of extracts of various cell lines, using NTRK3 antibody (STJ115968) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-NTRK3 antibody (40-300) (STJ115968)

SKU:
STJ115968

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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-NTRK3 (40-300) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NTRK3
Gene ID: 4916
Uniprot ID: NTRK3_HUMAN
Immunogen Region: 40-300
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 40-300 of human TrKC (NP_001007157.1).
Immunogen Sequence: KTEINCRRPDDGNLFPLLEG QDSGNSNGNASINITDISRN ITSIHIENWRSLHTLNAVDM ELYTGLQKLTIKNSGLRSIQ PRAFAKNPHLRYINLSSNRL TTLSWQLFQTLSLRELQLEQ NFFNCSCDIRWMQLWQEQGE AKLNSQNLYCINADGSQLPL FRMNISQCDLPEISVSHVNL TVREGDNAVITCNGSGSPLP DVDWIVTGLQSINTHQTNLN WTNVHAINLTLVNVTSEDN
Tissue Specificity Widely expressed but mainly in nervous tissue. Isoform 2 is expressed at higher levels in adult brain than in fetal brain.
Post Translational Modifications Ligand-mediated auto-phosphorylation.
Function Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
Protein Name Nt-3 Growth Factor Receptor
Gp145-Trkc
Trk-C
Neurotrophic Tyrosine Kinase Receptor Type 3
Trkc Tyrosine Kinase
Database Links Reactome: R-HSA-388844
Reactome: R-HSA-9034013
Reactome: R-HSA-9034015
Reactome: R-HSA-9034793
Reactome: R-HSA-9034864
Reactome: R-HSA-9603381
Reactome: R-HSA-9603505
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Nt-3 Growth Factor Receptor antibody
Anti-Gp145-Trkc antibody
Anti-Trk-C antibody
Anti-Neurotrophic Tyrosine Kinase Receptor Type 3 antibody
Anti-Trkc Tyrosine Kinase antibody
Anti-NTRK3 antibody
Anti-TRKC antibody

Information sourced from Uniprot.org

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