Anti-OCA2 antibody

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Product name Anti-OCA2 antibody
Short Description Rabbit polyclonal against OCA2
Description This gene encodes the human homolog of the mouse p (pink-eyed dilution) gene. The encoded protein is believed to be an integral membrane protein involved in small molecule transport, specifically tyrosine, which is a precursor to melanin synthesis. It is involved in mammalian pigmentation, where it may control skin color variation and act as a determinant of brown or blue eye color. Mutations in this gene result in type 2 oculocutaneous albinism. Alternative splicing results in multiple transcript variants.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name P Protein
Melanocyte-Specific Transporter Protein
Pink-Eyed Dilution Protein Homolog
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human OCA2 (NP_000266. 2).
Storage Instruction Store at -20°C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 4948
Gene Symbol OCA2
Molecular Weight Calculated: 74kDa/90kDa/92kDa. Observed: 65-80kDa
Alternative Names Anti-P Protein antibody
Anti-Melanocyte-Specific Transporter Protein antibody
Anti-Pink-Eyed Dilution Protein Homolog antibody
Anti-OCA2 D15S12 P antibody
Function Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color.
Cellular Localization Melanosome Membrane
Multi-Pass Membrane Protein
Swiss-Prot Key P_HUMAN
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