Anti-PARP-3 antibody

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Anti-PARP-3 antibody

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Product name Anti-PARP-3 antibody
Short Description Rabbit polyclonal against PARP-3
Description Rabbit polyclonal to PARP-3.
Applications ELISA, IHC-p
Dilution range IHC 1:100-1:300
ELISA 1:5000
Specificity PARP-3 polyclonal antibody detects endogenous levels of PARP-3 protein.
Protein Name Protein Mono-Adp-Ribosyltransferase Parp3
Adp-Ribosyltransferase Diphtheria Toxin-Like 3
Dna Adp-Ribosyltransferase Parp3
Nad(+ Adp-Ribosyltransferase 3
Poly [Adp-Ribose] Polymerase 3
Poly[Adp-Ribose] Synthase 3
Immunogen Synthesized peptide derived from human PARP-3
Immunogen Region 10-90 aa, N-terminal
Storage Instruction Store at-20°C, and avoid repeat freeze-thaw cycles.
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 10039
Gene Symbol PARP3
Molecular Weight 60.089 kDa
Database Links HGNC:273
Alternative Names Anti-Protein Mono-Adp-Ribosyltransferase Parp3 antibody
Anti-Adp-Ribosyltransferase Diphtheria Toxin-Like 3 antibody
Anti-Artd3 antibody
Anti-Dna Adp-Ribosyltransferase Parp3 antibody
Anti-Irt1 antibody
Anti-Nad(+ Adp-Ribosyltransferase 3 antibody
Anti-Adprt-3 antibody
Anti-Poly [Adp-Ribose] Polymerase 3 antibody
Anti-Parp-3 antibody
Anti-Hparp-3 antibody
Anti-Poly[Adp-Ribose] Synthase 3 antibody
Anti-Padprt-3 antibody
Anti-PARP3 ADPRT3 ADPRTL3 antibody
Function Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins and plays a key role in the response to DNA damage. Mediates mono-ADP-ribosylation of glutamate, aspartate or lysine residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Associates with a number of DNA repair factors and is involved in the response to exogenous and endogenous DNA strand breaks. Together with APLF, promotes the retention of the LIG4-XRCC4 complex on chromatin and accelerate DNA ligation during non-homologous end-joining (NHEJ). Cooperates with the XRRC6-XRCC5 (Ku70-Ku80) heterodimer to limit end-resection thereby promoting accurate NHEJ. Involved in DNA repair by mediating mono-ADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism, such as XRRC5 and XRCC6. ADP-ribosylation follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. In addition to proteins, also able to ADP-ribosylate DNA: mediates DNA mono-ADP-ribosylation of DNA strand break termini via covalent addition of a single ADP-ribose moiety to a 5'-or 3'-terminal phosphate residues in DNA containing multiple strand breaks. Acts as a negative regulator of immunoglobulin class switch recombination, probably by controlling the level of AICDA/AID on the chromatin.
Post-translational Modifications Auto-mono-ADP-ribosylated.
Cellular Localization Nucleus
Microtubule Organizing Center
Almost Exclusively Localized In The Nucleus And Appears In Numerous Small Foci And A Small Number Of Larger Foci Whereas A Centrosomal Location Has Not Been Detected
In Response To Dna Damage
Localizes To Sites Of Double-Strand Break
Preferentially Localized To The Daughter Centriole
Tissue Specificity Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.
Swiss-Prot Key PARP3_HUMAN
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