• Western blot analysis of extracts of various cell lines, using PGLYRP1 antibody (STJ112489) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.

Anti-PGLYRP1 antibody (22-196) (STJ112489)

SKU:
STJ112489

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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PGLYRP1 (22-196) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PGLYRP1
Gene ID: 8993
Uniprot ID: PGRP1_HUMAN
Immunogen Region: 22-196
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 22-196 of human PGLYRP1 (NP_005082.1).
Immunogen Sequence: QETEDPACCSPIVPRNEWKA LASECAQHLSLPLRYVVVSH TAGSSCNTPASCQQQARNVQ HYHMKTLGWCDVGYNFLIGE DGLVYEGRGWNFTGAHSGHL WNPMSIGISFMGNYMDRVPT PQAIRAAQGLLACGVAQGAL RSNYVLKGHRDVQRTLSPGN QLYHLIQNWPHYRSP
Tissue Specificity Highly expressed in bone marrow. Weak expression found in kidney, liver, small intestine, spleen, thymus, peripheral leukocyte, lung, fetal spleen and neutrophils.
Post Translational Modifications N-glycosylated. N-glycosylation is required for bactericidal activity.
Function Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity. Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane. In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement. Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system. Promotes also the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity. Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor.
Protein Name Peptidoglycan Recognition Protein 1
Peptidoglycan Recognition Protein Short
Pgrp-S
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-6803157
Cellular Localisation Secreted
Cytoplasmic Granule
Alternative Antibody Names Anti-Peptidoglycan Recognition Protein 1 antibody
Anti-Peptidoglycan Recognition Protein Short antibody
Anti-Pgrp-S antibody
Anti-PGLYRP1 antibody
Anti-PGLYRP antibody
Anti-PGRP antibody
Anti-TNFSF3L antibody
Anti-SBBI68 antibody
Anti-UNQ639 antibody
Anti-PRO1269 antibody

Information sourced from Uniprot.org

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