Anti-Phospho-AKT (Thr342) antibody (KLH)

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Product name Anti-Phospho-AKT (Thr342) antibody (KLH)
Description The serine/threonine kinase Akt also known as protein kinase B (PKB) or Rac, plays a crucial role in controlling many diverse and important cellular functions such as cell survival and glycogen metabolism (Hajduch et al., 2001 and Nicholson & Anderson, 2002). Three isoforms (α, β, and γ) have been identified that can be activated rapidly in response to insulin and growth factors in a phosphoinositide 3-kinase (PI3K)- dependent fashion (Hajduch et al., 2003). Phosphorylation of Aktα occurs at two specific regulatory sites in Drosophila, one localized 342 in the kinase domain, Thr , and the other in the C-terminal 505 regulatory domain, Ser these two activation sites are 473 308 homologous to mammalian Ser and Thr respectively (Powell et al., 2004).
Applications WB
Dilution range WB 1:500
Immunogen Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr342 conjugated to KLH.
Storage Instruction Store at -20°C, and avoid repeated freeze-thaw cycles.
Note For research use only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Drosophila
Conjugation KLH
Purification This antibody was antigen affinity purified from pooled serum.
Formulation 100 µl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Gene ID 41957
Molecular Weight 68 kDa
Swiss-Prot Key Q8INB9
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