Anti-Phospho-MAPK3-(Y204) Antibody

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Product name Anti-Phospho-MAPK3-(Y204) Antibody
Short Description Rabbit polyclonal against Phospho-MAPK3-(Y204)
Description The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
Applications IF, IHC, WB
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:100
IF 1:100 - 1:200
Protein Name Mitogen-activated protein kinase 3
MAP kinase 3
MAPK 3
Immunogen A phospho specific peptide corresponding to residues surrounding Y204 of human MAPK3
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB IHC IF
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 5595
Gene Symbol MAPK3
Molecular Weight 43.136 kDa
Database Links HGNC:6877
OMIM:601795
Reactome:R-HSA-110056
Alternative Names Mitogen-activated protein kinase 3
MAP kinase 3
MAPK 3
Function Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway, MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade, They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF, Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements, The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors, About 160 substrates have already been discovered for ERKs, Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation, However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis, Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC)
Post-translational Modifications Phosphorylated upon KIT and FLT3 signaling , Dually phosphorylated on Thr-202 and Tyr-204, which activates the enzyme, Ligand-activated ALK induces tyrosine phosphorylation, Dephosphorylated by PTPRJ at Tyr-204,
Cellular Localization Cytoplasm, Nucleus, Membrane, caveola,
Swiss-Prot Key P27361
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