Anti-Phospho-MAPK6-(S189) antibody

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Product name Anti-Phospho-MAPK6-(S189) antibody
Short Description Rabbit polyclonal against Phospho-MAPK6-(S189)
Description The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Mitogen-Activated Protein Kinase 6
Map Kinase 6
Mapk 6
Extracellular Signal-Regulated Kinase 3
Map Kinase Isoform P97
Immunogen A phospho specific peptide corresponding to residues surrounding S189 of human ERK3
Storage Instruction Store at -20°C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 5597
Gene Symbol MAPK6
Molecular Weight Calculated: 82kDa. Observed: 120kDa
Alternative Names Anti-Mitogen-Activated Protein Kinase 6 antibody
Anti-Map Kinase 6 antibody
Anti-Mapk 6 antibody
Anti-Extracellular Signal-Regulated Kinase 3 antibody
Anti-Erk-3 antibody
Anti-Map Kinase Isoform P97 antibody
Anti-P97-Mapk antibody
Anti-MAPK6 ERK3 PRKM6 antibody
Function Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle.
Post-translational Modifications Phosphorylated at Ser-189 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites. ; Ubiquitination at Met-1 leads to degradation by the proteasome pathway.
Cellular Localization Cytoplasm
Translocates To The Cytoplasm Following Interaction With Mapkapk5
Tissue Specificity Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.
Swiss-Prot Key MK06_HUMAN
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