Anti-PIEZO1 antibody

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Product name Anti-PIEZO1 antibody
Short Description Rabbit polyclonal against PIEZO1
Description The protein encoded by this gene is a mechanically-activated ion channel that links mechanical forces to biological signals. The encoded protein contains 36 transmembrane domains and functions as a homotetramer. Defects in this gene have been associated with dehydrated hereditary stomatocytosis.
Applications WB
Dilution range WB 1:500-1:2000
Protein Name Piezo-Type Mechanosensitive Ion Channel Component 1
Membrane Protein Induced By Beta-Amyloid Treatment
Mib
Protein Fam38a
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 2230-2420 of human PIEZO1 (NP_001136336. 2).
Storage Instruction Store at-20°C and avoid freeze-thaw cycles.
Note FOR RESEARCH USE ONLY (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 9780
Gene Symbol PIEZO1
Molecular Weight Calculated: 286kDa. Observed: 300kDa
Alternative Names Anti-Piezo-Type Mechanosensitive Ion Channel Component 1 antibody
Anti-Membrane Protein Induced By Beta-Amyloid Treatment antibody
Anti-Mib antibody
Anti-Protein Fam38a antibody
Anti-PIEZO1 FAM38A KIAA0233 antibody
Function Pore-forming subunit of a mechanosensitive non-specific cation channel. Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling. In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology.
Cellular Localization Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Cell Membrane
Cell Projection
Lamellipodium Membrane
In Erythrocytes
Located In The Plasma Membrane
Accumulates At The Leading Apical Lamellipodia Of Endothelial Cells In Response To Shear Stress
Tissue Specificity Expressed in numerous tissues. In normal brain, expressed exclusively in neurons, not in astrocytes. In Alzheimer disease brains, expressed in about half of the activated astrocytes located around classical senile plaques. In Parkinson disease substantia nigra, not detected in melanin-containing neurons nor in activated astrocytes. Expressed in erythrocytes (at protein level).
Swiss-Prot Key PIEZ1_HUMAN
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