Anti-PIEZO1 Antibody

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Product name Anti-PIEZO1 Antibody
Short Description Rabbit polyclonal against PIEZO1
Description The protein encoded by this gene is a mechanically-activated ion channel that links mechanical forces to biological signals. The encoded protein contains 36 transmembrane domains and functions as a homotetramer. Defects in this gene have been associated with dehydrated hereditary stomatocytosis.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Piezo-type mechanosensitive ion channel component 1
Membrane protein induced by beta-amyloid treatment
Mib
Protein FAM38A
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 2230-2420 of human PIEZO1 (NP_001136336.2).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 9780
Gene Symbol PIEZO1
Molecular Weight 286.79 kDa
Database Links HGNC:28993
OMIM:194380
Alternative Names Piezo-type mechanosensitive ion channel component 1
Membrane protein induced by beta-amyloid treatment
Mib
Protein FAM38A
Function Pore-forming subunit of a mechanosensitive non-specific cation channel ,
Cellular Localization Endoplasmic reticulum membrane,
Tissue Specificity Expressed in numerous tissues, In normal brain, expressed exclusively in neurons, not in astrocytes, In Alzheimer disease brains, expressed in about half of the activated astrocytes located around classical senile plaques, In Parkinson disease substantia nigra, not detected in melanin-containing neurons nor in activated astrocytes, Expressed in erythrocytes (at protein level)
Swiss-Prot Key Q92508
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