| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PJA2 (439-708) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PJA2 |
| Gene ID: |
9867 |
| Uniprot ID: |
PJA2_HUMAN |
| Immunogen Region: |
439-708 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 439-708 of human PJA2 (NP_055634.3). |
| Immunogen Sequence: |
SLPHRFSGTEKDQSSSDESW ETLPGKDENEPELQSDSSGP EEENQELSLQEGEQTSLEEG EIPWLQYNEVNESSSDEGNE PANEFAQPAFMLDGNNNLED DSSVSEDLDVDWSLFDGFAD GLGVAEAISYVDPQFLTYMA LEERLAQAMETALAHLESLA VDVEVANPPASKESIDGLPE TLVLEDHTAIGQEQCCPICC SEYIKDDIATELPCHHFFHK PCVSIWLQKSGTCPVCRRH |
| Function | Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype. Plays a role in ciliogenesis by ubiquitinating OFD1. |
| Protein Name | E3 Ubiquitin-Protein Ligase Praja-2Praja2Ring Finger Protein 131Ring-Type E3 Ubiquitin Transferase Praja-2 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCell MembraneEndoplasmic Reticulum MembranePeripheral Membrane ProteinGolgi Apparatus MembraneSynapsePostsynaptic DensityCytoskeletonMicrotubule Organizing CenterCentrosomeLocalizes At The Cytoplasmic Side Of Endoplasmic Reticulum And Golgi ApparatusExpressed In The Postsynaptic Density Region Of SynapsesColocalizes With Prkar2a And Prkar2b In The Cytoplasm And The Cell Membrane |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Praja-2 antibodyAnti-Praja2 antibodyAnti-Ring Finger Protein 131 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Praja-2 antibodyAnti-PJA2 antibodyAnti-KIAA0438 antibodyAnti-RNF131 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
