| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PMEPA1 (173-252) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PMEPA1 |
| Gene ID: |
56937 |
| Uniprot ID: |
PMEPA_HUMAN |
| Immunogen Region: |
173-252 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 173-252 of human PMEPA1 (NP_954638.1). |
| Immunogen Sequence: |
PSSNSGISATCYGSGGRMEG PPPTYSEVIGHYPGSSFQHQ QSSGPPSLLEGTRLHHTHIA PLESAAIWSKEKDKQKGHPL |
| Tissue Specificity | Highest expression in prostate. Also expressed in ovary. |
| Function | Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal. Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4. |
| Protein Name | Protein TmepaiProstate Transmembrane Protein Androgen Induced 1Solid Tumor-Associated 1 ProteinTransmembrane Prostate Androgen-Induced Protein |
| Database Links | Reactome: R-HSA-2173788 |
| Cellular Localisation | Early Endosome MembraneSingle-Pass Membrane ProteinGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Protein Tmepai antibodyAnti-Prostate Transmembrane Protein Androgen Induced 1 antibodyAnti-Solid Tumor-Associated 1 Protein antibodyAnti-Transmembrane Prostate Androgen-Induced Protein antibodyAnti-PMEPA1 antibodyAnti-STAG1 antibodyAnti-TMEPAI antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
