• Western blot analysis of extracts of various cell lines, using PMPCB antibody (STJ114423) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.

Anti-PMPCB antibody (110-380) (STJ114423)

SKU:
STJ114423

£169.50 - £449.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PMPCB (110-380) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PMPCB
Gene ID: 9512
Uniprot ID: MPPB_HUMAN
Immunogen Region: 110-380
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 110-380 of human PMPCB (NP_004270.2).
Immunogen Sequence: GTKKRSQLDLELEIENMGAH LNAYTSREQTVYYAKAFSKD LPRAVEILADIIQNSTLGEA EIERERGVILREMQEVETNL QEVVFDYLHATAYQNTALGR TILGPTENIKSISRKDLVDY ITTHYKGPRIVLAAAGGVSH DELLDLAKFHFGDSLCTHKG EIPALPPCKFTGSEIRVRDD KMPLAHLAIAVEAVGWAHPD TICLMVANTLIGNWDRSFGG GMNLSSKLAQLTCHGNLCH
Function Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (Probable). Preferentially, cleaves after an arginine at position P2. Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis.
Protein Name Mitochondrial-Processing Peptidase Subunit Beta
Beta-Mpp
P-52
Database Links Reactome: R-HSA-1268020
Reactome: R-HSA-8949664
Cellular Localisation Mitochondrion Matrix
Alternative Antibody Names Anti-Mitochondrial-Processing Peptidase Subunit Beta antibody
Anti-Beta-Mpp antibody
Anti-P-52 antibody
Anti-PMPCB antibody
Anti-MPPB antibody

Information sourced from Uniprot.org

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