Anti-PNPT1 antibody

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Product name Anti-PNPT1 antibody
Short Description Rabbit polyclonal against PNPT1
Description The protein encoded by this gene belongs to the evolutionary conserved polynucleotide phosphorylase family comprised of phosphate dependent 3'-to-5' exoribonucleases implicated in RNA processing and degradation. This enzyme is predominantly localized in the mitochondrial intermembrane space and is involved in import of RNA to mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency-13 and autosomal recessive nonsyndromic deafness-70. Related pseudogenes are found on chromosomes 3 and 7.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Polyribonucleotide Nucleotidyltransferase 1 - Mitochondrial
3'-5' Rna Exonuclease Old35
Pnpase Old-35
Polynucleotide Phosphorylase 1
Pnpase 1
Polynucleotide Phosphorylase-Like Protein
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PNPT1 (NP_149100. 2).
Storage Instruction Store at -20°C and avoid freeze-thaw cycles.
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Gene ID 87178
Gene Symbol PNPT1
Molecular Weight Calculated: 85kDa. Observed: 110kDa
Alternative Names Anti-Polyribonucleotide Nucleotidyltransferase 1 - Mitochondrial antibody
Anti-3'-5' Rna Exonuclease Old35 antibody
Anti-Pnpase Old-35 antibody
Anti-Polynucleotide Phosphorylase 1 antibody
Anti-Pnpase 1 antibody
Anti-Polynucleotide Phosphorylase-Like Protein antibody
Anti-PNPT1 PNPASE antibody
Function RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration.regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity.degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells.specifically and selectively degrades miR-221, preferentially. Plays also a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA.
Cellular Localization Cytoplasm
Mitochondrion Matrix
Mitochondrion Intermembrane Space
Peripheral Membrane Protein
Swiss-Prot Key PNPT1_HUMAN
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