Anti-POMC Antibody

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Product name Anti-POMC Antibody
Short Description Rabbit polyclonal against POMC
Description This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Pro-opiomelanocortin
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-267 of human POMC (NP_000930.1).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 5443
Gene Symbol POMC
Molecular Weight 29.424 kDa
Database Links HGNC:9201
Alternative Names Pro-opiomelanocortin
Function Corticotropin: Stimulates the adrenal glands to release cortisol
Post-translational Modifications Specific enzymatic cleavages at paired basic residues yield the different active peptides,
Cellular Localization Secreted
Tissue Specificity ACTH and MSH are produced by the pituitary gland
Swiss-Prot Key P01189
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Li C-W, Pan W-T, Ju J-C, Wang G-J. An endothelial cultured condition medium embedded porous PLGA scaffold for the enhancement of mouse embryonic stem cell differentiation. Biomedical Materials. 11 (2016) 025015.  Mater. 11 (2016) 025015 6041/11/2/025015. 

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