| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-POMK (1-350) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
POMK |
| Gene ID: |
84197 |
| Uniprot ID: |
SG196_HUMAN |
| Immunogen Region: |
1-350 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human POMK (NP_115613.1). |
| Immunogen Sequence: |
MEKQPQNSRRGLAPREVPPA VGLLLIMALMNTLLYLCLDH FFIAPRQSTVDPTHCPYGHF RIGQMKNCSPWLSCEELRTE VRQLKRVGEGAVKRVFLSEW KEHKVALSQLTSLEMKDDFL HGLQMLKSLQGTHVVTLLGY CEDDNTMLTEYHPLGSLSNL EETLNLSKYQNVNTWQHRLE LAMDYVSIINYLHHSPVGTR VMCDSNDLPKTLSQYLLTSN FSILANDLDALPLVNHSSG |
| Tissue Specificity | Highest expression is observed in brain, skeletal muscle, kidney and heart in fetal and adult tissues. |
| Function | Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif. |
| Protein Name | Protein O-Mannose KinasePomkProtein Kinase-Like Protein Sgk196Sugen Kinase 196 |
| Database Links | Reactome: R-HSA-5173105 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Protein O-Mannose Kinase antibodyAnti-Pomk antibodyAnti-Protein Kinase-Like Protein Sgk196 antibodyAnti-Sugen Kinase 196 antibodyAnti-POMK antibodyAnti-SGK196 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
