| Host: | Rabbit |
| Applications: | WB/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-PPP2R1A (1-270) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000IF/ICC 1:10-1:100 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PPP2R1A |
| Gene ID: | 5518 |
| Uniprot ID: | 2AAA_HUMAN |
| Immunogen Region: | 1-270 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human PP2A-Aalpha/PR65 Alpha/PP2A-A Alpha/PR65 Alpha/PPP2R1A (NP_055040.2). |
| Immunogen Sequence: | MAAADGDDSLYPIAVLIDEL RNEDVQLRLNSIKKLSTIAL ALGVERTRSELLPFLTDTIY DEDEVLLALAEQLGTFTTLV GGPEYVHCLLPPLESLATVE ETVVRDKAVESLRAISHEHS PSDLEAHFVPLVKRLAGGDW FTSRTSACGLFSVCYPRVSS AVKAELRQYFRNLCSDDTPM VRRAAASKLGEFAKVLELDN VKSEIIPMFSNLASDEQDSV RLLAVEACVNIAQLLPQED |
| Function | The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis. Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway. Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability. |
| Protein Name | Serine/Threonine-Protein Phosphatase 2a 65 Kda Regulatory Subunit A Alpha IsoformMedium Tumor Antigen-Associated 61 Kda ProteinPp2a Subunit A Isoform Pr65-AlphaPp2a Subunit A Isoform R1-Alpha |
| Database Links | Reactome: R-HSA-113501Reactome: R-HSA-1295596Reactome: R-HSA-141444Reactome: R-HSA-163685Reactome: R-HSA-163767Reactome: R-HSA-180024Reactome: R-HSA-195253Reactome: R-HSA-196299Reactome: R-HSA-198753Reactome: R-HSA-202670Reactome: R-HSA-2465910Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-2565942Reactome: R-HSA-2995383Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-389513Reactome: R-HSA-432142Reactome: R-HSA-4641262Reactome: R-HSA-5339716Reactome: R-HSA-5358747Reactome: R-HSA-5358749Reactome: R-HSA-5358751Reactome: R-HSA-5358752Reactome: R-HSA-5467337Reactome: R-HSA-5467340Reactome: R-HSA-5467348Reactome: R-HSA-5620912Reactome: R-HSA-5663220Reactome: R-HSA-5673000Reactome: R-HSA-5675221Reactome: R-HSA-6804757Reactome: R-HSA-6811558Reactome: R-HSA-68877Reactome: R-HSA-69231Reactome: R-HSA-69273Reactome: R-HSA-8854518Reactome: R-HSA-9634600Reactome: R-HSA-9648025Reactome: R-HSA-975957 |
| Cellular Localisation | CytoplasmNucleusChromosomeCentromereLateral Cell MembraneCell ProjectionDendriteCentromeric Localization Requires The Presence Of Bub1 |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Phosphatase 2a 65 Kda Regulatory Subunit A Alpha Isoform antibodyAnti-Medium Tumor Antigen-Associated 61 Kda Protein antibodyAnti-Pp2a Subunit A Isoform Pr65-Alpha antibodyAnti-Pp2a Subunit A Isoform R1-Alpha antibodyAnti-PPP2R1A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
