| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PRLR (25-234) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PRLR |
| Gene ID: |
5618 |
| Uniprot ID: |
PRLR_HUMAN |
| Immunogen Region: |
25-234 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 25-234 of human Prolactin Receptor (NP_000940.1). |
| Immunogen Sequence: |
QLPPGKPEIFKCRSPNKETF TCWWRPGTDGGLPTNYSLTY HREGETLMHECPDYITGGPN SCHFGKQYTSMWRTYIMMVN ATNQMGSSFSDELYVDVTYI VQPDPPLELAVEVKQPEDRK PYLWIKWSPPTLIDLKTGWF TLLYEIRLKPEKAAEWEIHF AGQQTEFKILSLHPGQKYLV QVRCKPDHGYWSAWSPATFI QIPSDFTMND |
| Tissue Specificity | Expressed in breast, placenta, kidney, liver and pancreas. |
| Function | This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. |
| Protein Name | Prolactin ReceptorPrl-R |
| Database Links | Reactome: R-HSA-1170546Reactome: R-HSA-982772 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinIsoform 7: Secreted |
| Alternative Antibody Names | Anti-Prolactin Receptor antibodyAnti-Prl-R antibodyAnti-PRLR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
