Anti-PROCR antibody

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Product name Anti-PROCR antibody
Short Description Rabbit polyclonal against PROCR
Description The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Endothelial Protein C Receptor
Activated Protein C Receptor
Apc Receptor
Endothelial Cell Protein C Receptor
Cd Antigen Cd201
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 18-210 of human PROCR (NP_006395. 2).
Storage Instruction Store at -20°C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 10544
Gene Symbol PROCR
Molecular Weight Calculated: 26kDa. Observed: 45kDa
Alternative Names Anti-Endothelial Protein C Receptor antibody
Anti-Activated Protein C Receptor antibody
Anti-Apc Receptor antibody
Anti-Endothelial Cell Protein C Receptor antibody
Anti-Cd Antigen Cd201 antibody
Anti-PROCR EPCR antibody
Function Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex. plays a role in the protein C pathway controlling blood coagulation.
Post-translational Modifications N-glycosylated. ; A soluble form exists; probably released by a metalloprotease. Seems to have the same activity as the membrane-bound form.
Cellular Localization Membrane
Single-Pass Type I Membrane Protein
Tissue Specificity Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney.
Swiss-Prot Key EPCR_HUMAN
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