Anti-PROCR Antibody

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Product name Anti-PROCR Antibody
Short Description Rabbit polyclonal against PROCR
Description The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Endothelial protein C receptor
Activated protein C receptor
APC receptor
Endothelial cell protein C receptor
CD antigen CD201
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 18-210 of human PROCR (NP_006395.2).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 10544
Gene Symbol PROCR
Molecular Weight 26.671 kDa
Database Links HGNC:9452
OMIM:600646
Reactome:R-HSA-140875
Alternative Names Endothelial protein C receptor
Activated protein C receptor
APC receptor
Endothelial cell protein C receptor
CD antigen CD201
Function Binds activated protein C, Enhances protein C activation by the thrombin-thrombomodulin complex
Post-translational Modifications N-glycosylated,
Cellular Localization Membrane
Tissue Specificity Expressed strongly in the endothelial cells of arteries and veins in heart and lung, less intensely in capillaries in the lung and skin, and not at all in the endothelium of small vessels of the liver and kidney
Swiss-Prot Key Q9UNN8
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