Anti-PSAP antibody

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Product name Anti-PSAP antibody
Short Description Mouse monoclonal against PSAP
Description Prostatic Specific Acid Phosphatase (PSAP) is a prostatic enzyme found in the glandular epithelium of the prostate. PSAP levels are elevated in hyperplastic prostate and prostate carcinoma, with the highest levels being detected in metastasized prostate cancer. Moderate overexpression of PSAP is also characteristic of diseases of the bone (such as Paget's disease or hyperparathyroidism), diseases of blood cells (such as sickle-cell disease), multiple myeloma, or lysosomal storage diseases (such as Gaucher's disease). PSAP is considered more sensitive, yet less specific, than PSA, however Anti-PSAP can act as a useful complement to Anti-PSA under suitable clinical contexts.
Applications IHC
Dilution range 1:100 - 1:200
Protein Name Prosaposin
Proactivator polypeptide
Immunogen Human PSAP protein.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application IHC
Host Mouse
Clonality Monoclonal
Reactivity Human
Conjugation Unconjugated
Formulation Tris Buffer, pH 7.3 - 7.7, with 1% BSA and <0.1% Sodium Azide
Gene ID 5660
Gene Symbol PSAP
Molecular Weight 58.2 kDa
Database Links HGNC:9498
Alternative Names Prosaposin
Proactivator polypeptide
Function Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3,2,1,45) and galactosylceramide by beta-galactosylceramidase (EC 3,2,1,46), Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate.
Post-translational Modifications The lysosomal precursor is proteolytically processed to 4 small peptides, which are similar to each other and are sphingolipid hydrolase activator proteins
Cellular Localization Lysosome
Swiss-Prot Key P07602
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