| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PTPRA (175-295) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PTPRA |
| Gene ID: |
5786 |
| Uniprot ID: |
PTPRA_HUMAN |
| Immunogen Region: |
175-295 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 175-295 of human PTPRA (NP_543030.1). |
| Immunogen Sequence: |
GSHSNSFRLSNGRTEDVEPQ SVPLLARSPSTNRKYPPLPV DKLEEEINRRMADDNKLFRE EFNALPACPIQATCEAASKE ENKEKNRYVNILPYDHSRVH LTPVEGVPDSDYINASFING Y |
| Post Translational Modifications | Integrin binding to extracellular matrix induces phosphorylation at Tyr-798 which induces PTPRA localization and recruitment of BCAR3, BCAR1 and CRK to focal adhesions. |
| Function | Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation. Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase AlphaProtein-Tyrosine Phosphatase AlphaR-Ptp-Alpha |
| Database Links | Reactome: R-HSA-375165Reactome: R-HSA-5673001 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell JunctionFocal AdhesionLocalizes To Focal Adhesion Sites Following Integrin Engagement |
| Alternative Antibody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase Alpha antibodyAnti-Protein-Tyrosine Phosphatase Alpha antibodyAnti-R-Ptp-Alpha antibodyAnti-PTPRA antibodyAnti-PTPA antibodyAnti-PTPRL2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
