| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PTPRR (240-400) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PTPRR |
| Gene ID: |
5801 |
| Uniprot ID: |
PTPRR_HUMAN |
| Immunogen Region: |
240-400 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 240-400 of human PTPRR (NP_002840.2). |
| Immunogen Sequence: |
IIVTCLMILYRLKERFQLSL RQDKEKNQEIHLSPITLQPA LSEAKTVHSMVQPEQAPKVL NVVVDPQGRGAPEIKATTAT SVCPSPFKMKPIGLQERRGS NVSLTLDMSSLGNIEPFVSI PTPREKVAMEYLQSASRILT RSQLRDVVASSHLLQSEFME I |
| Tissue Specificity | Detected in cerebrospinal fluid (at protein level). Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta, prostate, small intestine and uterus. |
| Function | Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase RR-Ptp-RCh-1ptpaseNc-Ptpcom1Protein-Tyrosine Phosphatase Pcptp1 |
| Cellular Localisation | SecretedIsoform Alpha: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform Delta: CytoplasmPerinuclear RegionLocates To The Perinuclear Areas Within The CytoplasmIsoform Gamma: Cytoplasm |
| Alternative Antibody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase R antibodyAnti-R-Ptp-R antibodyAnti-Ch-1ptpase antibodyAnti-Nc-Ptpcom1 antibodyAnti-Protein-Tyrosine Phosphatase Pcptp1 antibodyAnti-PTPRR antibodyAnti-ECPTP antibodyAnti-PTPRQ antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
