• Western blot analysis of extracts of mouse brain cells, using PTPRU antibody (STJ110773) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.

Anti-PTPRU antibody (1-100) (STJ110773)

SKU:
STJ110773

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Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PTPRU (1-100) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PTPRU
Gene ID: 10076
Uniprot ID: PTPRU_HUMAN
Immunogen Region: 1-100
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PTPRU (NP_005695.3).
Immunogen Sequence: MARAQALVLALTFQLCAPET ETPAAGCTFEEASDPAVPCE YSQAQYDDFQWEQVRIHPGT RAPADLPHGSYLMVNTSQHA PGQRAHVIFQSLSENDTHCV
Tissue Specificity High levels in brain, pancreas, and skeletal muscle.less in colon, kidney, liver, stomach, and uterus.not expressed in placenta and spleen. Also detected in heart, prostate, lung, thymus, testis and ovary. Ubiquitously expressed in brain. Expressed by hematopoietic stem cells.
Post Translational Modifications The extracellular domain is proteolytically processed through cleavage within the fibronectin type-III 4 domain. In addition to the 190 kDa full-length protein, proteolytic products of 100 kDa, 80 kDa and 73 kDa are observed. N-glycosylated. Phosphorylated on tyrosine residues upon activation of KIT with stem cell factor (SCF). The 73 kDa proteolytic product is not phosphorylated.
Function Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.
Protein Name Receptor-Type Tyrosine-Protein Phosphatase U
R-Ptp-U
Pancreatic Carcinoma Phosphatase 2
Pcp-2
Protein-Tyrosine Phosphatase J
Ptp-J
Hptp-J
Protein-Tyrosine Phosphatase Pi
Ptp Pi
Protein-Tyrosine Phosphatase Receptor Omicron
Ptp-Ro
Receptor-Type Protein-Tyrosine Phosphatase Psi
R-Ptp-Psi
Database Links Reactome: R-HSA-1433557
Cellular Localisation Cell Junction
Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Receptor-Type Tyrosine-Protein Phosphatase U antibody
Anti-R-Ptp-U antibody
Anti-Pancreatic Carcinoma Phosphatase 2 antibody
Anti-Pcp-2 antibody
Anti-Protein-Tyrosine Phosphatase J antibody
Anti-Ptp-J antibody
Anti-Hptp-J antibody
Anti-Protein-Tyrosine Phosphatase Pi antibody
Anti-Ptp Pi antibody
Anti-Protein-Tyrosine Phosphatase Receptor Omicron antibody
Anti-Ptp-Ro antibody
Anti-Receptor-Type Protein-Tyrosine Phosphatase Psi antibody
Anti-R-Ptp-Psi antibody
Anti-PTPRU antibody
Anti-FMI antibody
Anti-PCP2 antibody
Anti-PTPRO antibody

Information sourced from Uniprot.org

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