| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RAB23 (1-237) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RAB23 |
| Gene ID: |
51715 |
| Uniprot ID: |
RAB23_HUMAN |
| Immunogen Region: |
1-237 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-237 of human RAB23 (NP_057361.3). |
| Immunogen Sequence: |
MLEEDMEVAIKMVVVGNGAV GKSSMIQRYCKGIFTKDYKK TIGVDFLERQIQVNDEDVRL MLWDTAGQEEFDAITKAYYR GAQACVLVFSTTDRESFEAV SSWREKVVAEVGDIPTVLVQ NKIDLLDDSCIKNEEAEALA KRLKLRFYRTSVKEDLNVNE VFKYLAEKYLQKLKQQIAED PELTHSSSNKIGVFNTSGGS HSGQNSGTLNGGDVINLRPN KQRTKKNRNPFSSCSIP |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes. |
| Protein Name | Ras-Related Protein Rab-23 |
| Database Links | Reactome: R-HSA-8873719 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideCytoplasmCytoplasmic VesicleAutophagosomeEndosome MembranePhagosomePhagosome MembraneRecruited To Phagosomes Containing SAureus Or MTuberculosis |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-23 antibodyAnti-RAB23 antibodyAnti-HSPC137 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
