| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RAB25 (1-213) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RAB25 |
| Gene ID: |
57111 |
| Uniprot ID: |
RAB25_HUMAN |
| Immunogen Region: |
1-213 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-213 of human RAB25 (NP_065120.2). |
| Immunogen Sequence: |
MGNGTEEDYNFVFKVVLIGE SGVGKTNLLSRFTRNEFSHD SRTTIGVEFSTRTVMLGTAA VKAQIWDTAGLERYRAITSA YYRGAVGALLVFDLTKHQTY AVVERWLKELYDHAEATIVV MLVGNKSDLSQAREVPTEEA RMFAENNGLLFLETSALDST NVELAFETVLKEIFAKVSKQ RQNSIRTNAITLGSAQAGQE PGPGEKRACCISL |
| Tissue Specificity | Expressed in ovarian epithelium (NOE) and breast tissue. Expressed in ovarian cancer.expression is increased relative to NOE cells. Expression in ovarian cancer is stage dependent, with stage III and stage IV showing higher levels than early stage cancers. Expressed in breast cancer.expression is increased relative to normal breast tissue. |
| Function | Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis. |
| Protein Name | Ras-Related Protein Rab-25Catx-8 |
| Database Links | Reactome: R-HSA-8873719 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideCell ProjectionPseudopodium MembraneCytoplasmic VesicleColocalizes With Integrin Alpha-V/Beta-1 In Vesicles At The Pseudopodial Tips |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-25 antibodyAnti-Catx-8 antibodyAnti-RAB25 antibodyAnti-CATX8 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
