Anti-ROBO1 antibody

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Product name Anti-ROBO1 antibody
Short Description Rabbit polyclonal against ROBO1
Description Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene.
Applications WB
Dilution range WB 1:500-1:2000
Protein Name Roundabout Homolog 1
Deleted In U Twenty Twenty
H-Robo-1
Immunogen A synthetic peptide of human ROBO1
Storage Instruction Store at 4°C and avoid freeze-thaw cycles.
Note FOR RESEARCH USE ONLY (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, pH7.3.
Gene ID 6091
Gene Symbol ROBO1
Molecular Weight Calculated: 169kDa/175kDa/176kDa/180kDa/181kDa. Observed: 240kDa
Database Links Reactome: R-HSA-373752
Alternative Names Anti-Roundabout Homolog 1 antibody
Anti-Deleted In U Twenty Twenty antibody
Anti-H-Robo-1 antibody
Anti-ROBO1 DUTT1 antibody
Function Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. Plays a role in the regulation of cell migration via its interaction with MYO9B.inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA. May be required for lung development.
Post-translational Modifications Ubiquitinated. May be deubiquitinated by USP33.
Cellular Localization Cell Membrane
Single-Pass Type I Membrane Protein
Cell Projection
Axon
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
Single-Pass Membrane Protein
Detected At Growth Cones In Thalamus Neurons
Prrg4 Prevents Cell Surface Location And Both Colocalize In The Endoplasmic Reticulum/Golgi Adjacent To The Cell Nucleus
Tissue Specificity Widely expressed, with exception of kidney.
Swiss-Prot Key ROBO1_HUMAN
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