Anti-ROBO1 antibody

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Anti-ROBO1 antibody

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Product name Anti-ROBO1 antibody
Short Description Rabbit polyclonal against ROBO1
Description Unconjugated Rabbit polyclonal to ROBO1
Applications ELISA, WB
Dilution range WB 1:500-2000
ELISA 1:5000-20000
Specificity ROBO1 polyclonal antibody detects endogenous levels of protein.
Protein Name Roundabout homolog 1
Deleted in U twenty twenty
H-Robo-1
Immunogen Synthesized peptide derived from human ROBO1 protein.
Immunogen Region 730-810aa
Storage Instruction Store at-20°C, and avoid repeat freeze-thaw cycles.
Note FOR RESEARCH USE ONLY (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification ROBO1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene ID 6091
Gene Symbol ROBO1
Molecular Weight 181 kDa
Database Links HGNC:10249
OMIM:602430
Alternative Names Roundabout homolog 1
Deleted in U twenty twenty
H-Robo-1
Function Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1. In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex. Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA. May be required for lung development.
Post-translational Modifications Ubiquitinated. May be deubiquitinated by USP33.
Cellular Localization Cell membrane Cell projection, axon. Detected at growth cones in thalamus neurons.
Tissue Specificity Widely expressed, with exception of kidney.
Swiss-Prot Key Q9Y6N7_HUMAN
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