• Western blot analysis of lysates from Rat uterus, using ROR1 Rabbit polyclonal antibody (STJ25381) at 1:800 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-ROR1 antibody (24-937) (STJ25381)

SKU:
STJ25381

£169.50 - £449.50
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Host: Rabbit
Applications: WB
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ROR1 (24-937) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ROR1
Gene ID: 4919
Uniprot ID: ROR1_HUMAN
Immunogen Region: 24-937
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 24-937 of human ROR1 (NP_005003.2).
Immunogen Sequence: ARGAAAQETELSVSAELVPT SSWNISSELNKDSYLTLDEP MNNITTSLGQTAELHCKVSG NPPPTIRWFKNDAPVVQEPR RLSFRSTIYGSRLRIRNLDT TDTGYFQCVATNGKEVVSST GVLFVKFGPPPTASPGYSDE YEEDGFCQPYRGIACARFIG NRTVYMESLHMQGEIENQIT AAFTMIGTSSHLSDKCSQFA IPSLCHYAFPYCDETSSVPK PRDLCRDECEILENVLCQT
Tissue Specificity Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.
Function Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells.
Protein Name Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1
Neurotrophic Tyrosine Kinase - Receptor-Related 1
Database Links Reactome: R-HSA-5140745
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Cell Projection
Axon
Alternative Antibody Names Anti-Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1 antibody
Anti-Neurotrophic Tyrosine Kinase - Receptor-Related 1 antibody
Anti-ROR1 antibody
Anti-NTRKR1 antibody

Information sourced from Uniprot.org

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