• Western blot analysis using SARS-M monoclonal antibody against SARS-mpm recombinant protein.

Anti-SARS-M antibody [2H2C4] (STJ98378)

SKU:
STJ98378

Current Stock:
Host: Mouse
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-SARS1 is suitable for use in Western Blot and ELISA research applications.
Clonality: Monoclonal
Clone ID: 2H2C4
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Subclonal supernatant.
Purification: Affinity purification
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Specificity: SARS-M Monoclonal Antibody detects SARS-M protein.
Immunogen: Purified recombinant fragment of SARS-M protein expressed in E. Coli.
Function Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.
Protein Name Serine--Trna Ligase - Cytoplasmic
Seryl-Trna Synthetase
Serrs
Seryl-Trna(Ser/Sec Synthetase
Database Links Reactome: R-HSA-2408557
Reactome: R-HSA-379716
Cellular Localisation Cytoplasm
Nucleus
Predominantly Cytoplasmic
But A Minor Proportion Is Also Found In The Nucleus
Alternative Antibody Names Anti-Serine--Trna Ligase - Cytoplasmic antibody
Anti-Seryl-Trna Synthetase antibody
Anti-Serrs antibody
Anti-Seryl-Trna(Ser/Sec Synthetase antibody
Anti-SARS1 antibody
Anti-SARS antibody
Anti-SERS antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance