| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SF3B6 (1-125) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SF3B6 |
| Gene ID: |
51639 |
| Uniprot ID: |
SF3B6_HUMAN |
| Immunogen Region: |
1-125 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-125 of human SF3B6 (NP_057131.1). |
| Immunogen Sequence: |
MAMQAAKRANIRLPPEVNRI LYIRNLPYKITAEEMYDIFG KYGPIRQIRVGNTPETRGTA YVVYEDIFDAKNACDHLSGF NVCNRYLVVLYYNANRAFQK MDTKKKEEQLKLLKEKYGIN TDPPK |
| Function | Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively. |
| Protein Name | Splicing Factor 3b Subunit 6Pre-Mrna Branch Site Protein P14Sf3b 14 Kda SubunitSf3b14aSpliceosome-Associated Protein - 14-KdaSplicing Factor 3b - Subunit 6 - 14kda |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72165 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Splicing Factor 3b Subunit 6 antibodyAnti-Pre-Mrna Branch Site Protein P14 antibodyAnti-Sf3b 14 Kda Subunit antibodyAnti-Sf3b14a antibodyAnti-Spliceosome-Associated Protein - 14-Kda antibodyAnti-Splicing Factor 3b - Subunit 6 - 14kda antibodyAnti-SF3B6 antibodyAnti-SAP14 antibodyAnti-SF3B14 antibodyAnti-SF3B14A antibodyAnti-CGI-110 antibodyAnti-HSPC175 antibodyAnti-HT006 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
