| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SIGLEC5 (17-551) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SIGLEC5 |
| Gene ID: |
8778 |
| Uniprot ID: |
SIGL5_HUMAN |
| Immunogen Region: |
17-551 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 17-551 of human SIGLEC5 (NP_003821.1). |
| Immunogen Sequence: |
EKPVYELQVQKSVTVQEGLC VLVPCSFSYPWRSWYSSPPL YVYWFRDGEIPYYAEVVATN NPDRRVKPETQGRFRLLGDV QKKNCSLSIGDARMEDTGSY FFRVERGRDVKYSYQQNKLN LEVTALIEKPDIHFLEPLES GRPTRLSCSLPGSCEAGPPL TFSWTGNALSPLDPETTRSS ELTLTPRPEDHGTNLTCQMK RQGAQVTTERTVQLNVSYAP QTITIFRNGIALEILQNTS |
| Tissue Specificity | Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation. |
| Function | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. |
| Protein Name | Sialic Acid-Binding Ig-Like Lectin 5Siglec-5Cd33 Antigen-Like 2Obesity-Binding Protein 2Ob-Bp2Ob-Binding Protein 2Cd Antigen Cd170 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-6798695 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Sialic Acid-Binding Ig-Like Lectin 5 antibodyAnti-Siglec-5 antibodyAnti-Cd33 Antigen-Like 2 antibodyAnti-Obesity-Binding Protein 2 antibodyAnti-Ob-Bp2 antibodyAnti-Ob-Binding Protein 2 antibodyAnti-Cd Antigen Cd170 antibodyAnti-SIGLEC5 antibodyAnti-CD33L2 antibodyAnti-OBBP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
