| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SIK2 (827-926) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SIK2 |
| Gene ID: |
23235 |
| Uniprot ID: |
SIK2_HUMAN |
| Immunogen Region: |
827-926 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 827-926 of human SIK2 (NP_056006.1). |
| Immunogen Sequence: |
PPPPPPRQPGAAPAPLQFSY QTCELPSAASPAPDYPTPCQ YPVDGAQQSDLTGPDCPRSP GLQEAPSSYDPLALSELPGL FDCEMLDAVDPQHNGYVLVN |
| Post Translational Modifications | Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylated at Thr-484 in response to insulin in adipocytes. Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC6. |
| Function | Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism. Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. Phosphorylates EP300 and thus inhibits its histone acetyltransferase activity. In turn, regulates the DNA-binding ability of several transcription factors such as PPARA or MLXIPL. Also plays a role in thymic T-cell development. |
| Protein Name | Serine/Threonine-Protein Kinase Sik2Qin-Induced KinaseSalt-Inducible Kinase 2Sik-2Serine/Threonine-Protein Kinase Snf1-Like Kinase 2 |
| Cellular Localisation | CytoplasmEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Sik2 antibodyAnti-Qin-Induced Kinase antibodyAnti-Salt-Inducible Kinase 2 antibodyAnti-Sik-2 antibodyAnti-Serine/Threonine-Protein Kinase Snf1-Like Kinase 2 antibodyAnti-SIK2 antibodyAnti-KIAA0781 antibodyAnti-QIK antibodyAnti-SNF1LK2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
