| Host: |
Rabbit |
| Applications: |
IF |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC25A6 (1-298) is suitable for use in Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IF 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC25A6 |
| Gene ID: |
293 |
| Uniprot ID: |
ADT3_HUMAN |
| Immunogen Region: |
1-298 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-298 of human SLC25A6 (NP_001627.2). |
| Immunogen Sequence: |
MTEQAISFAKDFLAGGIAAA ISKTAVAPIERVKLLLQVQH ASKQIAADKQYKGIVDCIVR IPKEQGVLSFWRGNLANVIR YFPTQALNFAFKDKYKQIFL GGVDKHTQFWRYFAGNLASG GAAGATSLCFVYPLDFARTR LAADVGKSGTEREFRGLGDC LVKITKSDGIRGLYQGFSVS VQGIIIYRAAYFGVYDTAKG MLPDPKNTHIVVSWMIAQTV TAVAGVVSYPFDTVRRRMM |
| Tissue Specificity | Expressed in erythrocytes (at protein level). |
| Post Translational Modifications | Trimethylated by ANTKMT at Lys-52. |
| Function | ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane. In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity. Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A6/ANT3 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it. Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death. It is however unclear if SLC25A6/ANT3 constitutes a pore-forming component of mPTP or regulates it. |
| Protein Name | Adp/Atp Translocase 3Adp -Atp Carrier Protein 3Adp -Atp Carrier Protein - Isoform T2Ant 2Adenine Nucleotide Translocator 3Ant 3Solute Carrier Family 25 Member 6 Cleaved Into - Adp/Atp Translocase 3 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-1268020Reactome: R-HSA-168277Reactome: R-HSA-180897Reactome: R-HSA-83936 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane ProteinMembraneThe Complex Formed With Arl2bpArl2 And Slc25a6/Ant3 Is Expressed In MitochondriaMay Localize To Non-Mitochondrial Membranes |
| Alternative Antibody Names | Anti-Adp/Atp Translocase 3 antibodyAnti-Adp -Atp Carrier Protein 3 antibodyAnti-Adp -Atp Carrier Protein - Isoform T2 antibodyAnti-Ant 2 antibodyAnti-Adenine Nucleotide Translocator 3 antibodyAnti-Ant 3 antibodyAnti-Solute Carrier Family 25 Member 6 Cleaved Into - Adp/Atp Translocase 3 - N-Terminally Processed antibodyAnti-SLC25A6 antibodyAnti-AAC3 antibodyAnti-ANT3 antibodyAnti-CDABP0051 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
