| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC38A3 (1-65) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC38A3 |
| Gene ID: |
10991 |
| Uniprot ID: |
S38A3_HUMAN |
| Immunogen Region: |
1-65 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-65 of human SLC38A3 (NP_006832.1). |
| Immunogen Sequence: |
MEAPLQTEMVELVPNGKHSE GLLPVITPMAGNQRVEDPAR SCMEGKSFLQKSPSKEPHFT DFEGK |
| Function | Symporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity. Mainly participates in the glutamate-GABA-glutamine cycle in brain where it transports L-glutamine from astrocytes in the intercellular space for the replenishment of both neurotransmitters glutamate and gamma-aminobutyric acid (GABA) in neurons and also functions as the major influx transporter in ganglion cells mediating the uptake of glutamine. The transport activity is specific for L-glutamine, L-histidine and L-asparagine. The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+). The transport is pH dependent, saturable, Li(+) tolerant and functions in both direction depending on the concentration gradients of its substrates and cotransported ions. Also mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport. In addition, may play a role in nitrogen metabolism, amino acid homeostasis, glucose metabolism and renal ammoniagenesis. |
| Protein Name | Sodium-Coupled Neutral Amino Acid Transporter 3N-System Amino Acid Transporter 1Na(+-Coupled Neutral Amino Acid Transporter 3Solute Carrier Family 38 Member 3System N Amino Acid Transporter 1 |
| Database Links | Reactome: R-HSA-352230 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneThe Localization Appears To Be Basolateral In The Plasma Membrane Of Hepatocytes Surrounding The Central VeinLocalized At The Cerebrospinal Fluid (Csf)-Facing Membrane Of The Choroid Plexus Epithelial CellsIn AstrocytesThe Localization At Cell Membrane Is Decreased By Ammonia Through The Pkc SignalingExpressed In Both Luminal And Abluminal Plasma Membranes Of Larger Microvessels And Blood Brain Barrier (Bbb) CapillariesRestricted To The Basolateral Membranes Of S3 Segment Cells Of The Proximal Tubules |
| Alternative Antibody Names | Anti-Sodium-Coupled Neutral Amino Acid Transporter 3 antibodyAnti-N-System Amino Acid Transporter 1 antibodyAnti-Na(+-Coupled Neutral Amino Acid Transporter 3 antibodyAnti-Solute Carrier Family 38 Member 3 antibodyAnti-System N Amino Acid Transporter 1 antibodyAnti-SLC38A3 antibodyAnti-G17 antibodyAnti-NAT1 antibodyAnti-SN1 antibodyAnti-SNAT3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
