• Western blot analysis of extracts of various cell lines, using SRRM1 antibody (STJ27860) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
  • Immunohistochemistry of paraffin-embedded human esophageal cancer using SRRM1 rabbit polyclonal antibody (STJ27860) at dilution of 1:450 (40x lens).
  • Immunohistochemistry of paraffin-embedded mouse testis using SRRM1 rabbit polyclonal antibody (STJ27860) at dilution of 1:450 (40x lens).

Anti-SRRM1 antibody (1-160) (STJ27860)

SKU:
STJ27860

Shipping:
Free Shipping
Current Stock:
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SRRM1 (1-160) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IHC-P 1:100-1:500
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SRRM1
Gene ID: 10250
Uniprot ID: SRRM1_HUMAN
Immunogen Region: 1-160
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human SRRM1 (NP_005830.2).
Immunogen Sequence: MDAGFFRGTSAEQDNRFSNK QKKLLKQLKFAECLEKKVDM SKVNLEVIKPWITKRVTEIL GFEDDVVIEFIFNQLEVKNP DSKMMQINLTGFLNGKNARE FMGELWPLLLSAQENIAGIP SAFLELKKEEIKQRQIEQEK LASMKKQDEDKDKRDKEEKE
Post Translational Modifications Phosphorylated on multiple serine and threonine residues by DYRK3 during the G2-to-M transition, after the nuclear-envelope breakdown. Phosphorylation by DYRK3 promotes disassembly of nuclear speckles. Citrullinated by PADI4.
Function Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates.
Protein Name Serine/Arginine Repetitive Matrix Protein 1
Sr-Related Nuclear Matrix Protein Of 160 Kda
Srm160
Ser/Arg-Related Nuclear Matrix Protein
Database Links Reactome: R-HSA-159236
Reactome: R-HSA-72163
Reactome: R-HSA-72187
Reactome: R-HSA-73856
Reactome: R-HSA-9013418
Reactome: R-HSA-9013422
Cellular Localisation Nucleus Matrix
Nucleus Speckle
Alternative Antibody Names Anti-Serine/Arginine Repetitive Matrix Protein 1 antibody
Anti-Sr-Related Nuclear Matrix Protein Of 160 Kda antibody
Anti-Srm160 antibody
Anti-Ser/Arg-Related Nuclear Matrix Protein antibody
Anti-SRRM1 antibody
Anti-SRM160 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance