Anti-SRSF3 antibody

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Product name Anti-SRSF3 antibody
Short Description Rabbit polyclonal against SRSF3
Description The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Serine/Arginine-Rich Splicing Factor 3
Pre-Mrna-Splicing Factor Srp20
Splicing Factor - Arginine/Serine-Rich 3
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human SRSF3 (NP_003008. 1).
Storage Instruction Store at -20°C and avoid freeze-thaw cycles.
Host Rabbit
Clonality Polyclonal
Reactivity Hamster, Human, Mouse, Rat
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Gene ID 6428
Gene Symbol SRSF3
Molecular Weight Calculated: 14kDa/19kDa. Observed: 22kDa
Database Links Reactome: R-HSA-159236
Alternative Names Anti-Serine/Arginine-Rich Splicing Factor 3 antibody
Anti-Pre-Mrna-Splicing Factor Srp20 antibody
Anti-Splicing Factor - Arginine/Serine-Rich 3 antibody
Anti-SRSF3 SFRS3 SRP20 antibody
Function Splicing factor that specifically promotes exon-inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing. Also functions as export adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway).enhances NXF1-NXT1 RNA-binding activity. Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. RNA-binding is semi-sequence specific.
Post-translational Modifications Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Extensively phosphorylated on serine residues in the RS domain.
Cellular Localization Nucleus
Nucleus Speckle
Recruited To Nuclear Speckles Following Interaction With Ythdc1
Swiss-Prot Key SRSF3_HUMAN
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