Anti-THPO Antibody

[STJ25846] Download PDF Print Data Sheet

* Required Fields

£0.00
Product name Anti-THPO Antibody
Short Description Rabbit polyclonal against THPO
Description Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Thrombopoietin
C-mpl ligand
ML
Megakaryocyte colony-stimulating factor
Megakaryocyte growth and development factor
MGDF
Myeloproliferative leukemia virus oncogene ligand
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 22-349 of human THPO (NP_001171068.1).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 7066
Gene Symbol THPO
Molecular Weight 37.823 kDa
Database Links HGNC:11795
OMIM:187950
Reactome:R-HSA-76009
Alternative Names Thrombopoietin
C-mpl ligand
ML
Megakaryocyte colony-stimulating factor
Megakaryocyte growth and development factor
MGDF
Myeloproliferative leukemia virus oncogene ligand
Function Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells, It acts at a late stage of megakaryocyte development, It may be the major physiological regulator of circulating platelets
Cellular Localization Secreted
Swiss-Prot Key P40225
Bad Good
Enter the code in the box below:

Ask us a question

No questions yet. Be the first to ask the question!

Tags:

Use spaces to separate tags. Use single quotes (') for phrases.