Anti-THPO antibody

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Product name Anti-THPO antibody
Short Description Rabbit polyclonal against THPO
Description Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Thrombopoietin
C-Mpl Ligand
Megakaryocyte Colony-Stimulating Factor
Megakaryocyte Growth And Development Factor
Myeloproliferative Leukemia Virus Oncogene Ligand
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 22-349 of human THPO (NP_001171068. 1).
Storage Instruction Store at -20°C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Purification Affinity purification
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 7066
Gene Symbol THPO
Molecular Weight Calculated: 33kDa/37kDa. Observed: 32kDa
Alternative Names Anti-Thrombopoietin antibody
Anti-C-Mpl Ligand antibody
Anti-Ml antibody
Anti-Megakaryocyte Colony-Stimulating Factor antibody
Anti-Megakaryocyte Growth And Development Factor antibody
Anti-Mgdf antibody
Anti-Myeloproliferative Leukemia Virus Oncogene Ligand antibody
Anti-THPO MGDF antibody
Function Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Cellular Localization Secreted
Swiss-Prot Key TPO_HUMAN
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