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Anti-TMPO antibody

[STJ98661] Download PDF Print Data Sheet
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Product name Anti-TMPO antibody
Short Description Rabbit polyclonal to TMPO.
Description TMPO is a protein encoded by the TMPO gene which is approximately 75,4 kDa. TMPO is localised to the nucleus and is involved in the mitotic cell cycle, nuclear envelope reassembly, transport of the SLBP independent mature mRNA and apoptosis. It may be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly and plays an important role, together with LMNA, in the nuclear anchorage of RB1. It may also be involved in the control of initiation of DNA replication through its interaction with NAKAP95. TMPO is expressed in many tissues and is most abundant in adult thymus and fetal liver. Mutations in the TMPO gene result in dilated cardiomyopathy and dysentery. STJ98661 was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. This antibody detects endogenous TMPO protein.
Applications ELISA, IF, WB
Dilution range WB 1:5000-10000
ELISA 1:10000
Specificity The antibody detects endogenous TMPO protein
Protein Name Lamina-associated polypeptide 2, isoform alpha
Thymopoietin isoform alpha
TP alpha
Thymopoietin-related peptide isoform alpha
TPRP isoform alpha
Thymopoietin
TP
Splenin
Thymopentin
TP5
Immunogen Synthetic peptide from AA range: 1-50.
Immunogen Region 1-50 aa
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Isotype IgG
Formulation PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Gene ID 7112
Gene Symbol TMPO
Database Links HGNC:11875
OMIM:188380
Alternative Names Lamina-associated polypeptide 2, isoform alpha antibody
Thymopoietin isoform alpha antibody
TP alpha antibody
Thymopoietin-related peptide isoform alpha antibody
TPRP isoform alpha antibody
Thymopoietin antibody
TP antibody
Splenin antibody
Thymopentin antibody
TP5 antibody
LAP2 antibody
Function May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.; Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
Post-translational Modifications Mitosis-specific phosphorylation specifically abolishes its binding to lamin B and chromosomes. Citrullinated by PADI4.
Cellular Localization Nucleus inner membrane; Single-pass type II membrane protein.. Tightly associated with the nuclear lamina.; Isoform Zeta: Cytoplasm
Tissue Specificity Expressed in many tissues. Most abundant in adult thymus and fetal liver.
Sequence and Domain Family Has two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1.
Swiss-Prot Key P42166_HUMAN
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-1
I am interested in this antibody in 0.3mg size, 1mg/mL. Would it be possible to change the storage buffer to PBS and not include sodium azide?
Question by: Guest on 11 Apr 2018 13:40:00
-10
Hello, thank you for your query. If you would like to place a custom order, the product should be at least 1 mg. There will be no additional cost for changing the storage buffer. Please contact us at info@stjohnslabs.com for further information.
Answer by: Customer Support on 11 Apr 2018 13:43:00

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