Anti-TNKS2 antibody

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Anti-TNKS2 antibody

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Product name Anti-TNKS2 antibody
Short Description Rabbit polyclonal against TNKS2
Description Unconjugated Rabbit polyclonal to TNKS2
Applications ELISA, WB
Dilution range WB 1:500-2000 ELISA 1:5000-20000
Specificity TNKS2 Polyclonal Antibody detects endogenous levels of protein.
Protein Name Tankyrase-2
TANK2
ADP-ribosyltransferase diphtheria toxin-like 6
ARTD6
Poly
ADP-ribose polymerase 5B
TNKS-2
TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Tankyrase II
Tankyrase-like protein
Immunogen Synthesized peptide derived from human TNKS2 protein.
Immunogen Region 950-1030aa
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Concentration 1 mg/ml
Purification TNKS2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid form in PBS containing 50% glycerol,and 0.02% sodium azide.
Gene ID 80351
Gene Symbol TNKS2
Molecular Weight 128 kDa
Database Links HGNC:15677
OMIM:607128
Alternative Names Tankyrase-2
TANK2
ADP-ribosyltransferase diphtheria toxin-like 6
ARTD6
Poly
ADP-ribose polymerase 5B
TNKS-2
TRF1-interacting ankyrin-related ADP-ribose polymerase 2
Tankyrase II
Tankyrase-like protein
Function Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates poly-ADP-ribosylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates poly-ADP-ribosylation of TERF1, thereby contributing to the regulation of telomere length. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Stimulates 26S proteasome activity.
Post-translational Modifications Ubiquitinated at 'Lys-48' and 'Lys-63' by RNF146 when auto-poly-ADP-ribosylated; this leads to degradation.; ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination.; The crystallographic evidence suggests that the 3-hydroxyhistidine may be the (3S) stereoisomer.
Cellular Localization Cytoplasm. Golgi apparatus membrane. Peripheral membrane protein. Nucleus. Chromosome, telomere. Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. Also found around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS2 is found in the nucleus, associated with TRF1.
Tissue Specificity Highly expressed in placenta, skeletal muscle, liver, brain, kidney, heart, thymus, spinal cord, lung, peripheral blood leukocytes, pancreas, lymph nodes, spleen, prostate, testis, ovary, small intestine, colon, mammary gland, breast and breast carcinoma, and in common-type meningioma. Highly expressed in fetal liver, heart and brain.
Swiss-Prot Key Q9H2K2_HUMAN
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