Anti-TP53 antibody

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Product name Anti-TP53 antibody
Short Description Mouse monoclonal to TP53
Description p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to mdm2, SV40 T antigen and human papilloma virus E6 protein p53 senses DNA damage and possibly facilitating repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Applications IHC
Dilution range 1:100-200
Protein Name Cellular tumor antigen p53
Antigen NY-CO-13
Phosphoprotein p53
Tumor suppressor p53
Immunogen Recombinant human wild type p53 protein expressed in E. coli
Storage Instruction Store at 2-8°C for up to 1 year
Note For Research Use Only (RUO).
Validated Application IHC
Host Mouse
Clonality Monoclonal
Reactivity Human
Conjugation Unconjugated
Isotype IgG2b/k
Formulation Tissue culture supernatant with 0.2% BSA and 15mM sodium azide.
Gene ID 7157
Gene Symbol TP53
Molecular Weight 44 kDa
Database Links HGNC:11998
OMIM:133239
Reactome:R-HSA-111448
Alternative Names Cellular tumor antigen p53
Antigen NY-CO-13
Phosphoprotein p53
Tumor suppressor p53
Function Acts as a tumor suppressor in many tumor types
Post-translational Modifications Acetylated, Acetylation of Lys-382 by CREBBP enhances transcriptional activity, Deacetylation of Lys-382 by SIRT1 impairs its ability to induce proapoptotic program and modulate cell senescence, Deacetylation by SIRT2 impairs its ability to induce transcription activation in a AKT-dependent manner.
Cellular Localization Cytoplasm, Nucleus, Nucleus, PML body, Endoplasmic reticulum, Mitochondrion matrix, Cytoplasm
Tissue Specificity Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detec
Swiss-Prot Key P04637
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