Anti-TRα antibody

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Product name Anti-TRα antibody
Description Rabbit polyclonal to TRα.
Applications ELISA, IHC, WB
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
Specificity TRα Polyclonal Antibody detects endogenous levels of TRα protein.
Protein Name Thyroid hormone receptor alpha
Nuclear receptor subfamily 1 group A member 1
V-erbA-related protein 7
Immunogen Synthesized peptide derived from human TRα
Immunogen Region 10-90 aa, N-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application IHC
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 7067
Gene Symbol THRA
Molecular Weight 55 kDa
Database Links HGNC:11796
Alternative Names TRa
Thyroid hormone receptor alpha antibody
Nuclear receptor subfamily 1 group A member 1 antibody
V-erbA-related protein 7 antibody
EAR-7 antibody
c-erbA-1 antibody
c-erbA-alpha antibody
EAR7 antibody
ERBA1 antibody
NR1A1 antibody1 antibody2 antibody
Function Isoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Isoform Alpha-2: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action.
Cellular Localization Nucleus.
Sequence and Domain Family Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Swiss-Prot Key P10827_HUMAN
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