Anti-TRPV1 antibody

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Anti-TRPV1 antibody

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Product name Anti-TRPV1 antibody
Short Description Rabbit polyclonal against TRPV1
Description Unconjugated Rabbit polyclonal to TRPV1
Applications ELISA, WB
Dilution range WB 1:500-2000
ELISA 1:5000-20000
Specificity TRPV1 polyclonal antibody detects endogenous levels of protein.
Protein Name Transient receptor potential cation channel subfamily V member 1
Capsaicin receptor
Osm-9-like TRP channel 1
Vanilloid receptor 1
Immunogen Synthesized peptide derived from human TRPV1 protein.
Immunogen Region 440-520aa
Storage Instruction Store at-20°C, and avoid repeat freeze-thaw cycles.
Host Rabbit
Clonality Polyclonal
Reactivity Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification TRPV1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Gene ID 7442
Gene Symbol TRPV1
Molecular Weight 92 kDa
Database Links HGNC:12716
Alternative Names Transient receptor potential cation channel subfamily V member 1
Capsaicin receptor
Osm-9-like TRP channel 1
Vanilloid receptor 1
Function Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time-and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.
Post-translational Modifications Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phosphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PRKCE, PRKCM and probably PRKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity.
Cellular Localization Cell junction, synapse, postsynaptic cell membrane Cell projection, dendritic spine membrane Cell membrane. Mostly, but not exclusively expressed in postsynaptic dendritic spines.
Tissue Specificity Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).
Swiss-Prot Key Q8NER1_HUMAN
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