Anti-TRPV4 Antibody

[STJ27627] Download PDF Print Data Sheet

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Product name Anti-TRPV4 Antibody
Short Description Rabbit polyclonal against TRPV4
Description This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene.
Applications WB
Dilution range WB 1:500 - 1:2000
Protein Name Transient receptor potential cation channel subfamily V member 4
TrpV4
Osm-9-like TRP channel 4
OTRPC4
Transient receptor potential protein 12
TRP12
Vanilloid receptor-like channel 2
Vanilloid receptor-like protei
Immunogen A synthetic peptide corresponding to a sequence within amino acids 800 to the C-terminus of human TRPV4 (NP_067638.3).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 59341
Gene Symbol TRPV4
Molecular Weight 98.281 kDa
Database Links HGNC:18083
OMIM:113500
Reactome:R-HSA-3295583
Alternative Names Transient receptor potential cation channel subfamily V member 4
TrpV4
Osm-9-like TRP channel 4
OTRPC4
Transient receptor potential protein 12
TRP12
Vanilloid receptor-like channel 2
Vanilloid receptor-like protei
Function Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity, Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification ,
Cellular Localization Apical cell membrane
Tissue Specificity Found in the synoviocytes from patients with (RA) and without (CTR) rheumatoid arthritis (at protein level)
Swiss-Prot Key Q9HBA0
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