Anti-TRPV4 antibody

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Product name Anti-TRPV4 antibody
Short Description Rabbit polyclonal against TRPV4
Description Rabbit polyclonal to TRPV4.
Applications ELISA, WB
Dilution range WB 1:500-1:2000
ELISA 1:20000
Specificity TRPV4 polyclonal antibody detects endogenous levels of TRPV4 protein.
Protein Name Transient Receptor Potential Cation Channel Subfamily V Member 4
Trpv4
Osm-9-Like Trp Channel 4
Otrpc4
Transient Receptor Potential Protein 12
Trp12
Vanilloid Receptor-Like Channel 2
Vanilloid Receptor-Like Protein 2
Vrl-2
Vanilloid Receptor-Related Osmotically-Activated Channel
Vr-Oac
Immunogen Synthesized peptide derived from human TRPV4.
Immunogen Region Internal
Storage Instruction Store at-20°C, and avoid repeat freeze-thaw cycles.
Note FOR RESEARCH USE ONLY (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 59341
Gene Symbol TRPV4
Molecular Weight 98 kDa
Database Links HGNC:18083
OMIM:113500
Alternative Names Anti-Transient Receptor Potential Cation Channel Subfamily V Member 4 antibody
Anti-Trpv4 antibody
Anti-Osm-9-Like Trp Channel 4 antibody
Anti-Otrpc4 antibody
Anti-Transient Receptor Potential Protein 12 antibody
Anti-Trp12 antibody
Anti-Vanilloid Receptor-Like Channel 2 antibody
Anti-Vanilloid Receptor-Like Protein 2 antibody
Anti-Vrl-2 antibody
Anti-Vanilloid Receptor-Related Osmotically-Activated Channel antibody
Anti-Vr-Oac antibody
Anti-TRPV4 VRL2 VROAC antibody
Function Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by heat, low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12, 13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8. Together with PKD2, forms mechano-and thermosensitive channels in cilium. Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes. Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes. Together with AQP5, controls regulatory volume decrease in salivary epithelial cells. Required for normal development and maintenance of bone and cartilage. [Isoform 5]: Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by phorbol esters. Has the same channel activity as isoform 1, and is activated by the same stimuli. [Isoform 2]: Lacks channel activity, due to impaired oligomerization and intracellular retention. [Isoform 4]: Lacks channel activity, due to impaired oligomerization and intracellular retention. [Isoform 6]: Lacks channel activity, due to impaired oligomerization and intracellular retention.
Post-translational Modifications N-glycosylated.
Cellular Localization Apical Cell Membrane
Multi-Pass Membrane Protein
Cell Junction
Adherens Junction
Cell Projection
Cilium
Assembly Of The Putative Homotetramer Occurs Primarily In The Endoplasmic Reticulum
Isoform 1: Cell Membrane
Isoform 5: Cell Membrane
Isoform 2: Endoplasmic Reticulum
Isoform 4: Endoplasmic Reticulum
Isoform 6: Endoplasmic Reticulum
Tissue Specificity Found in the synoviocytes from patients with (RA) and without (CTR) rheumatoid arthritis (at protein level).
Swiss-Prot Key TRPV4_HUMAN
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