Anti-TRPV4 antibody

[STJ98664] Download PDF Print Data Sheet

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Product name Anti-TRPV4 antibody
Short Description Rabbit polyclonal against TRPV4
Description Rabbit polyclonal to TRPV4.
Applications ELISA, WB
Dilution range WB 1:500-2000
ELISA 1:10000-20000
Specificity The antibody detects endogenous TRPV4 protein
Protein Name Transient receptor potential cation channel subfamily V member 4
TrpV4
Osm-9-like TRP channel 4
OTRPC4
Transient receptor potential protein 12
TRP12
Vanilloid receptor-like channel 2
Vanilloid receptor-like protei
Immunogen Synthetic peptide from AA range: 461-510.
Immunogen Region 461-510 aa
Storage Instruction Store at-20°C, and avoid repeat freeze-thaw cycles.
Note FOR RESEARCH USE ONLY (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 59341
Gene Symbol TRPV4
Database Links HGNC:18083
OMIM:113500
Alternative Names Transient receptor potential cation channel subfamily V member 4
TrpV4
Osm-9-like TRP channel 4
OTRPC4
Transient receptor potential protein 12
TRP12
Vanilloid receptor-like channel 2
Vanilloid receptor-like protei
Function Non-selective calcium permeant cation channel involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by heat, low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12, 13-didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8. Together with PKD2, forms mechano-and thermosensitive channels in cilium. Negatively regulates expression of PPARGC1A, UCP1, oxidative metabolism and respiration in adipocytes. Regulates expression of chemokines and cytokines related to proinflammatory pathway in adipocytes. Together with AQP5, controls regulatory volume decrease in salivary epithelial cells. Required for normal development and maintenance of bone and cartilage.
Cellular Localization Apical cell membrane Cell projection, cilium. Assembly of the putative homotetramer occurs primarily in the endoplasmic reticulum. Isoform 1: Cell membrane.. Isoform 5: Cell membrane.
Tissue Specificity Found in the synoviocytes from patients with (RA) and without (CTR) rheumatoid arthritis (at protein level).
Swiss-Prot Key Q9HBA0_HUMAN
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-17
I am interested in this antibody in 0.3mg size, 1mg/mL. Would it be possible to change the storage buffer to PBS and not include sodium azide?
Question by: Guest on 11 Apr 2018 12:40:00
-11
Hello, thank you for your query. If you would like to place a custom order, the product should be at least 1 mg. There will be no additional cost for changing the storage buffer. Please contact us at [email protected] for further information.
Answer by: Customer Support on 11 Apr 2018 12:43:00

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