Anti-TSLC1 antibody

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Product name Anti-TSLC1 antibody
Short Description Rabbit polyclonal against TSLC1
Description Rabbit polyclonal to TSLC1.
Applications ELISA, IF, WB
Dilution range WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:20000
Specificity TSLC1 polyclonal antibody detects endogenous levels of TSLC1 protein.
Protein Name Cell Adhesion Molecule 1
Immunoglobulin Superfamily Member 4
Nectin-Like Protein 2
Spermatogenic Immunoglobulin Superfamily
Synaptic Cell Adhesion Molecule
Tumor Suppressor In Lung Cancer 1
Immunogen Synthesized peptide derived from human TSLC1
Immunogen Region 370-450 aa, C-terminal
Storage Instruction Store at-20°C, and avoid repeat freeze-thaw cycles.
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 23705
Gene Symbol CADM1
Molecular Weight 49 kDa
Database Links HGNC:5951
Alternative Names Anti-Cell Adhesion Molecule 1 antibody
Anti-Immunoglobulin Superfamily Member 4 antibody
Anti-Igsf4 antibody
Anti-Nectin-Like Protein 2 antibody
Anti-Necl-2 antibody
Anti-Spermatogenic Immunoglobulin Superfamily antibody
Anti-Sgigsf antibody
Anti-Synaptic Cell Adhesion Molecule antibody
Anti-Syncam antibody
Anti-Tumor Suppressor In Lung Cancer 1 antibody
Anti-Tslc-1 antibody
Function Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
Post-translational Modifications Glycosylation at Asn-67 and Asn-101 promotes adhesive binding and synapse induction.
Cellular Localization Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Localized To The Basolateral Plasma Membrane Of Epithelial Cells In Gall Bladder
Swiss-Prot Key CADM1_HUMAN
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