Anti-TSLC1 antibody

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Product name Anti-TSLC1 antibody
Description Rabbit polyclonal to TSLC1.
Applications ELISA, IF, IHC, WB
Dilution range WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:20000
Specificity TSLC1 Polyclonal Antibody detects endogenous levels of TSLC1 protein.
Protein Name Cell adhesion molecule 1
Immunoglobulin superfamily member 4
IgSF4
Nectin-like protein 2
NECL-2
Spermatogenic immunoglobulin superfamily
SgIgSF
Synaptic cell adhesion molecule
SynCAM
Tumor suppressor in lung cancer 1
TSLC-1
Immunogen Synthesized peptide derived from human TSLC1
Immunogen Region 370-450 aa, C-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB IHC
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 23705
Gene Symbol CADM1
Molecular Weight 49 kDa
Database Links HGNC:5951
OMIM:605686
Alternative Names TSLC1
Cell adhesion molecule 1 antibody
Immunoglobulin superfamily member 4 antibody
IgSF4 antibody
Nectin-like protein 2 antibody
NECL-2 antibody
Spermatogenic immunoglobulin superfamily antibody
SgIgSF antibody
Synaptic cell adhesion molecule antibody
SynCAM antibody
Tumor suppressor in lung cancer 1 antibody
TSLC-1 antibody
IGSF4 antibody
IGSF4A antibody
NECL2 antibody
SYNCAM antibody
TSLC1 antibody
Function Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly . May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
Post-translational Modifications Glycosylation at Asn-67 and Asn-101 promotes adhesive binding and synapse induction.
Cellular Localization Cell membrane Cell junction, synapse. Localized to the basolateral plasma membrane of epithelial cells in gall bladder.
Sequence and Domain Family The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC.
Swiss-Prot Key Q9BY67_HUMAN
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