Anti-TWEAK antibody

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Product name Anti-TWEAK antibody
Description Rabbit polyclonal to TWEAK.
Applications ELISA, IF, IHC, WB
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:20000
Specificity TWEAK Polyclonal Antibody detects endogenous levels of TWEAK protein.
Protein Name Tumor necrosis factor ligand superfamily member 12
APO3 ligand
TNF-related weak inducer of apoptosis
TWEAK
Tumor necrosis factor ligand superfamily member 12, membrane form
Tumor necrosis factor ligand superfamily member 12, secreted form
Immunogen Synthesized peptide derived from human TWEAK
Immunogen Region 10-90 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 407977
Gene Symbol TNFSF12
Molecular Weight 27 kDa
Database Links HGNC:11927
OMIM:602695
Alternative Names TWEAK
Tumor necrosis factor ligand superfamily member 12 antibody
APO3 ligand antibody
TNF-related weak inducer of apoptosis antibody
TWEAK antibody
Tumor necrosis factor ligand superfamily member 12, membrane form antibody
Tumor necrosis factor ligand superfamily member 12, secreted form antibody
APO3L antibody
DR3LG antibody
UNQ181/PRO207 antibody
Function Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.
Post-translational Modifications The soluble form derives from the membrane form by proteolytic processing.
Cellular Localization Cell membrane Tumor necrosis factor ligand superfamily member 12, secreted form: Secreted.. Isoform TWE-PRIL: Cell membrane. Single-pass membrane protein.
Tissue Specificity Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.
Swiss-Prot Key O43508_HUMAN
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