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Anti-VWF antibody

[STJ192142] Download PDF Print Data Sheet
Anti-VWF antibody
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Product name Anti-VWF antibody
Description Unconjugated Rabbit polyclonal to VWF
Applications IHC
Dilution range IHC-p 1:50-300
Specificity VWF Polyclonal Antibody detects endogenous levels of protein.
Protein Name von Willebrand factor
vWF
von Willebrand antigen 2
von Willebrand antigen II
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Expected Application IHC
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification VWF antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid form in PBS containing 50% glycerol,and 0.02% sodium azide.
Gene ID 7450
Gene Symbol VWF
Molecular Weight 309 kDa
Database Links HGNC:12726
OMIM:193400
Alternative Names von Willebrand factor antibody
vWF antibody
von Willebrand antigen 2 antibody
von Willebrand antigen II antibody
F8VWF antibody
Function Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
Post-translational Modifications All cysteine residues are involved in intrachain or interchain disulfide bonds.; N- and O-glycosylated.
Cellular Localization Secreted Secreted, extracellular space, extracellular matrix. Localized to storage granules.
Tissue Specificity Plasma.
Sequence and Domain Family The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules.
Swiss-Prot Key P04275_HUMAN
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