Anti-XRN2 antibody

[STJ96287] Download PDF Print Data Sheet

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Product name Anti-XRN2 antibody
Short Description Rabbit polyclonal against XRN2
Description Rabbit polyclonal to XRN2.
Applications ELISA, IHC, WB
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000
Specificity XRN2 Polyclonal Antibody detects endogenous levels of XRN2 protein.
Protein Name 5'-3' exoribonuclease 2
DHM1-like protein
DHP protein
Immunogen Synthesized peptide derived from human XRN2
Immunogen Region 50-130 aa, N-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Simian
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 22803
Gene Symbol XRN2
Molecular Weight 108 kDa
Database Links HGNC:12836
OMIM:608851
Alternative Names 5'-3' exoribonuclease 2
DHM1-like protein
DHP protein
Function Possesses 5'->3' exoribonuclease activity . May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites .
Cellular Localization Nucleus, nucleolus
Tissue Specificity Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes.
Swiss-Prot Key Q9H0D6_HUMAN
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