Anti-E2F6 Antibody

[STJ27904] Download PDF Print Data Sheet

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Product name Anti-E2F6 Antibody
Short Description Rabbit polyclonal against E2F6
Description This gene encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle. The protein encoded by this gene lacks the transactivation and tumor suppressor protein association domains found in other family members, and contains a modular suppression domain that functions in the inhibition of transcription. It interacts in a complex with chromatin modifying factors. There are pseudogenes for this gene on chromosomes 22 and X. Alternative splicing results in multiple transcript variants.
Applications ChIP, IF, IHC, IP, WB
Dilution range WB 1:500 - 1:2000
IHC 1:50 - 1:200
IF 1:20 - 1:100
IP 1:50 - 1:100
CHIP 1:20 - 1:50
Protein Name Transcription factor E2F6
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-281 of human E2F6 (NP_937987.2).
Storage Instruction Store at -20C. Avoid freeze / thaw cycles.
Note For Research Use Only (RUO).
Validated Application WB IHC IF IP ChIP
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Purification Affinity purification
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene ID 1876
Gene Symbol E2F6
Molecular Weight 31.844 kDa
Database Links HGNC:3120
Alternative Names Transcription factor E2F6
Function Inhibitor of E2F-dependent transcription, Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3', Has a preference for the 5'-TTTCCCGC-3' E2F recognition site, E2F6 lacks the transcriptional activation and pocket protein binding domains, Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression, May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity, Overexpression delays the exit of cells from the S-phase
Cellular Localization Nucleus
Tissue Specificity Expressed in all tissues examined, Highest levels in placenta, skeletal muscle, heart, ovary, kidney, small intestine and spleen
Swiss-Prot Key O75461
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