Anti-Integrin alpha antibody

[STJ97284] Download PDF Print Data Sheet

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Product name Anti-Integrin alpha antibody
Short Description Rabbit polyclonal against Integrin alpha
Description Integrin alpha5 is a protein encoded by the ITGA5 gene which is approximately 114, 5 kDa. Integrin alpha5 is localised to the cell membrane and is involved in the MAPK-Erk pathway, apoptotic pathways, integrin pathway, focal adhesion and blood-brain barrier and immune cell transmigration. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signalling. Integrin alpha5 is expressed in the liver, lung, nervous system, bone marrow and blood. Mutations in the ITGA5 gene may result in colon carcinoma and congenital epulis STJ97284 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Integrin alpha5 protein.
Applications ELISA, IHC-p, WB
Dilution range WB 1:500-1:2000
IHC-p 1:100-1:300
ELISA 1:10000
Specificity Integrin alpha 5 Polyclonal Antibody detects endogenous levels of Integrin alpha 5 protein.
Protein Name Integrin Alpha-5
Cd49 Antigen-Like Family Member E
Fibronectin Receptor Subunit Alpha
Integrin Alpha-F
Vla-5
Cd Antigen Cd49e [Cleaved Into-Integrin Alpha-5 Heavy Chain-Integrin Alpha-5 Light Chain]
Immunogen Synthesized peptide derived from human Integrin alpha5.
Immunogen Region 561-610 aa, Internal
Storage Instruction Store at-20°C, and avoid repeat freeze-thaw cycles.
Note FOR RESEARCH USE ONLY (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 3678
Gene Symbol ITGA5
Database Links HGNC:6141
OMIM:135620
Alternative Names Anti-Integrin Alpha-5 antibody
Anti-Cd49 Antigen-Like Family Member E antibody
Anti-Fibronectin Receptor Subunit Alpha antibody
Anti-Integrin Alpha-F antibody
Anti-Vla-5 antibody
Anti-Cd Antigen Cd49e [Cleaved Into-Integrin Alpha-5 Heavy Chain-Integrin Alpha-5 Light Chain] antibody
Anti-ITGA5 FNRA antibody
Function Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling. (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus. (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19. (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
Post-translational Modifications Proteolytic cleavage by PCSK5 mediates activation of the precursor.
Cellular Localization Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Focal Adhesion
Cell Surface
Swiss-Prot Key ITA5_HUMAN
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