Anti-Smo antibody

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Anti-Smo antibody

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Product name Anti-Smo antibody
Short Description Rabbit polyclonal against Smo
Description Rabbit polyclonal to Smo.
Applications ELISA, WB
Dilution range WB 1:500-1:2000
ELISA 1:10000
Specificity Smo Polyclonal Antibody detects endogenous levels of Smo protein.
Protein Name Smoothened homolog
Protein Gx
Immunogen Synthesized peptide derived from human Smo
Immunogen Region 40-120 aa, N-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 6608
Gene Symbol SMO
Molecular Weight 50 kDa
Database Links HGNC:11119
Alternative Names Smoothened homolog
Protein Gx
Function G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia . Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation .
Cellular Localization Membrane Cell projection, cilium
Swiss-Prot Key Q99835_HUMAN
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